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Etamzilat tablets: instructions, application, reviews

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Etamzilat is a hemostatic agent characterized by angioprotective and proagregantny action. The drug accelerates the development of platelets and their release from the bone marrow, normalizes the stability of the capillary walls, making them less perceptive. Able to increase the adhesiveness of platelets and inhibit the biosynthesis of prostaglandins.

The use of etamzilat accelerates the formation of a primary blood clot and enhances its retraction, practically without affecting the fibrinogen content in the blood and prothrombin time. Does not have hypercoagulable properties, use in therapeutic doses does not affect the formation of blood clots.

With intravenous administration (IV), the activation of the hemostasis process occurs within 5-15 minutes after the injection, and the maximum effect is achieved in 1-2 hours. The duration of the action is 4-6 hours.

When ingestion of etamzilat tablets, the maximum effect is recorded in 2-4 hours. The effective concentration of the active substance in the blood is 0.05-0.02 mg / ml. The drug is excreted in the urine (80%), in small amounts in the bile.

After completing the course of therapy, the therapeutic effect lasts 5–8 days, gradually weakening. High efficacy and a small number of contraindications of the drug provide positive feedback on etamzilat from doctors.

The drug is not prescribed for acute porphyria, thrombosis and pregnancy.

Dosage Form:

Etamzilat is available as a solution for intravenous and intramuscular injections, in tablets and tablets for children.

Indications for use etamzilat

According to the instructions for use of Etamzilat, the drug is used for monotherapy and in complex treatment regimens for:

  1. Stopping and preventing capillary bleeding on the background of diabetic angiopathy,
  2. Surgical interventions in otolaryngological practice (tonsillectomy, ear microsurgery and others),
  3. Ophthalmologic operations (cataract removal, keratoplasty, antiglaucomatous operations),
  4. Dental operations (removal of granulomas, cysts, tooth extraction),
  5. Urological operations (prostatectomy),
  6. Other, including gynecological, interventions - especially on organs and tissues with extensive blood circuits,
  7. Emergency care for pulmonary and intestinal bleeding,
  8. Hemorrhagic diathesis.

Instructions for use etamzilat - tablets and shots

Injections Etamzilat is administered intravenously and intramuscularly, in ophthalmic practice - in the form of eye drops and retrobulbar.

Standard dosage for adults:

Inside, a single dose of etamzilat for adults - 0.25-0.5 g, according to indications, the dosage can be increased to 0.75 g, parenterally - 0.125-0.25 g, if necessary, to 0.375 g.

Surgical interventions - in order to prevent etamzilat administered in in or in m for 1 hour before surgery at a dosage of 2-4 ml (1-2 ampoules) or inside 2-3 tablets (0.25 g) 3 hours before surgery .
If necessary, enter 2-4 ml of the drug in in during the operation.

At the risk of postoperative bleeding, 4 to 6 ml (2-4 ampoules) per day is injected, or 6 to 8 tablets of etamzilat per day are given. The dosage is distributed evenly over 24 hours.

Emergency: immediate injection in / in or intramuscularly, and then every 4-6 hours in / in, in / m or inside. Injection is recommended.

In the treatment of metro- and menorrhagia, the instructions for use of etamzilat in menses recommends the dosage of the drug to be 0.5 g orally or 0.25 g parenterally (bypassing the digestive tract) after 6 hours for 5-10 days.

After prophylaxis - 0.25 g orally 4 times every day, or 0.25 g parenterally 2 times every day during hemorrhage (bleeding) and two in subsequent cycles.

In case of diabetic myacroangiopathy injections, etamzilat is administered intramuscularly for 10-14 days in a single dose of 0.25-0.5 g 3 times a day or in courses for 2-3 months with a dosage of 1-2 tablets 3 times a day.

In hemorrhagic diathesis, the treatment regimen provides for administration of the drug in 1.5 g courses per day at regular intervals of time for 5-14 days. In severe cases, therapy begins with parenteral administration of 0.25-0.5 g 1-2 times a day for 3-8 days, and then administered orally.

When treating dysfunctional uterine bleeding, etamzilat needs to be ingested 0.6 grams every 6 hours. The duration of therapy is about 10 days. Then, a maintenance dose of 0.25 g is prescribed, 4 times a day, directly during bleeding (last 2 cycles). Parenteral 0.25 g administered 2 times a day.

In ophthalmology, the drug is administered subconjunctivally or retrobulbarly at a dose of 0.125 g (1 ml of 12.5% ​​solution).

Children:

In prophylactic operations, by mouth, at a dosage of 10-12 mg / kg in 2 doses for 3-5 days.

Extra during the operation - etamzilat injection 8-10 mg / kg body weight.

After surgery for the prevention of bleeding - inside, at 8 mg / kg.

When hemorrhagic syndrome in children etamzilat prescribed in a single dose of 6-8 mg / kg orally, 3 times a day. Duration of treatment is 5-14 days, if necessary, repeat the course after 7 days.

The drug is used in children over 6 years. Not prescribed in the presence of hemoblastosis.

Veterinarian:

Etamzilat is used in veterinary practice. The dosage for cats is 0.1 ml per kg of animal weight, 2 times per day (shots).

Contraindications Etamzilat

Contraindications of the drug are associated with increased thrombosis and associated conditions:

  • Hypersensitivity to the components of the drug,
  • Thrombosis, thromboembolism, increased blood clotting,
  • Acute form of porphyria
  • Hemoblastosis (lymphatic and myeloid leukemia, osteosarcoma) in children.

With caution when bleeding on the background of an overdose of anticoagulants.

Pharmaceutically incompatible with other drugs. Do not mix in the same syringe with other drugs and substances.

Side Effects of Etamzilat

  • feeling of discomfort or burning in the chest,
  • feeling of heaviness in the epigastric region,
  • headache and dizziness,
  • branching of the vascular network in the face,
  • decrease in systolic blood pressure,
  • unpleasant feeling of necrosis of the skin (numbness), the formation of "goosebumps" or unnatural, muffled soreness when touched.

Antami Etamzilat list

When searching for a replacement, note that the only registered full analogue of Etamzilat is Ditsinon. Other analogues on the effect on the body:

Any replacement of etamzilat with analogues should be agreed with the doctor! It is important to understand that this instruction on the use of tablets and injections Etamzilat does not apply to analogues and should not be used as a guide to action without an appointment and consultation with a physician.

Storage conditions
Store in a dark place away from children at a temperature not exceeding 25 ° C.

Etamzilat tablets instruction

The instruction suggests the patient to get acquainted with information about the drug Etamsylate for its successful treatment. Indications for use and dosing, contraindications and side effects, analogues, price, reviews - only a small part of the information provided in the instructions for the tablets Etamzilat.

Form, composition, packaging

The drug is available in tablet form. The tablet is round. White It has a separation risk.

Each tablet contains 250 milligrams of etamzilat, which is its active substance.

The packaging of the drug is a blister card. Each pack of pills accounts for 50 pieces.

Pharmacology

Etamzilat has a variety of pharmacological properties that contribute to its ability to stop blood. However, to study these properties until finally fails. It is allegedly claimed that the substance etamzilat by its action reduces the formation in the vessels of the blood supply of the metabolite of the archidonic acid, which in turn has a rather high activity. Due to this, successive transformations occur, as a result of which a thrombus is formed, which entails stopping the blood.

Etamzilat promotes the acceleration of the forming process, which occurs in the capillaries, as a result of which polymeric carbohydrate-protein complexes appear, where the advantage is over carbohydrate.

In addition, the active component contributes to the improvement of capillary capacity with respect to the integrity of the vessel wall for its preservation under the influence of a mechanical nature.

Thanks to etamzilat, an increase in the blood circulation occurs and vascular permeability is normalized, and indicators of blood retention in a liquid state are restored.

Etamzilat tablets indications

The drug has a number of indications for use:

  • in cases of limb lesions in order to stop the blood and prevent further capillary bleeding,
  • in the implementation of surgical intervention in the field of gynecology, ENT organs, urology, with pathologies of vision and diseases of the teeth and gums,
  • in case of unforeseen situations associated with bleeding of various etiologies, including internal bleeding in the intestinal or lung,
  • the drug is prescribed to patients for maintenance therapy if they suffer from a high degree of bleeding tendency.

Side effects

The drug Etamzilat is not deprived of a number of side effects that are not superfluous to provide for the appointment:

  • there is a burning sensation in the sternum and there is discomfort,
  • "Dead" areas of the skin, "goosebumps" or a sore feeling even when lightly touched,
  • epigastric heaviness
  • drop in blood pressure, which is associated with a violation of the rhythm of the heart,
  • migraine development
  • overflow of internal organs or vessels with accumulation of blood,
  • frequent and prolonged dizziness.

Etamzilat tablets reviews

Reviews of the drug are almost all positive and mostly come from women who solve their women's problems with the help of these pills. But each of them finds the drug effective and recommends it to her friends as a reliable assistant and ally for sensitive issues.

Hope: From a young age I suffer from a heavy monthly period. Doctors shrug their shoulders and try to help only by prescribing hemostatic drugs, among which there is etamzilat. I must say, the pills are quite effective, at least not worse than others (and I had to drink a lot of them all). The effect of the drug does not come immediately and you have to drink many pills sometimes, as I thought, as soon as I met them, but they still help. Before, I used them occasionally and therefore could not appreciate it. My doctor advised me to drink them a few days before the menstruation and then until it ends. So I did - quite another thing. Of course, the problem is far from being exhausted, but at least it is possible to function as it is, and not just lie in bed. Therefore, I recommend these tablets to those who are familiar with my problem. With etamzilat, it doesn't seem so big.

pharmachologic effect

Etamzilat is a means to prevent and stop bleeding. It affects the first stage of the hemostatic mechanism (the interaction between the endothelium and platelets). Etamzilat increases the adhesiveness of platelets, normalizes the resistance of the walls of capillaries, thus reducing their permeability, inhibits the biosynthesis of prostaglandins, causing disaggregation of platelets, vasodilation and increased capillary permeability. As a result, the bleeding time is significantly reduced, the blood loss is reduced.

Pharmacokinetics

After intravenous administration of the drug, the hemostatic effect is noted after 5-15 minutes, the maximum is achieved within 1 hour. The drug is effective for 4-6 hours, after which the effect gradually disappears. After intravenous administration of etamzilat in a dose of 500 mg, the highest plasma level is reached in 10 minutes and is 50 μg / ml.

Approximately 72% of the administered dose is excreted during the first 24 hours with the urine in an unchanged condition. The elimination half-life of etamzilat from blood plasma is approximately 2 hours. Etamzilat penetrates the placental barrier and is excreted into breast milk.

Pharmacodynamics and pharmacokinetics

The drug activates education thromboplastin andmucopolysaccharidesthereby manifesting hemostatic activity.

Normalizes the rate of blood coagulation, increases the stability and elasticity of the walls capillariesimproves processes microcirculation even in the smallest vessels and capillaries.

It is noteworthy that the drug does not affect prothrombin index and not conducive to education blood clots. If administered intravenously, the effect occurs within 10 minutes after the injection and lasts up to six to eight hours.

Instructions for use etamzilat (method and dosage)

The dosage, route of administration and duration of treatment should be determined by the doctor.

According to the instructions on etamzilat tablets, the drug is administered orally at 0.25-0.5 g (one or two tablets), distributed into 3 or 4 doses. For children, the daily dose is 10-15 mg per kg of weight, divided into 3 doses.

Etamzilat sodium in the solution for injection is used in the form of injections (intramuscularly intravenously) retro bulbar or subconjunctival, depending on the evidence.

The daily dose is 0.125-0.25 grams (for 3-4 applications), the maximum single dose is 0.75 g (parenterally - up to 0.375 g). Perhaps external use. A tampon soaked in the preparation is placed on the wound.

Apply the tool and in veterinary practice. The dosage for cats is 0.1 ml per kg of animal weight, injections are usually done twice a day.

Release form and composition

Etamzilat is available in the following dosage forms:

  • Convex round tablets, packs of 50 and 100 pieces.
  • Solution for injection in ampoules, has no color, transparent or slightly yellow. Packs of 1, 2 or 10 ampoules.

One drug tablet contains sodium etamzilat 0.25 g and excipients.

The solution for injection contains etamzilat 0.125 per 1 ml + excipients (water for injection, sodium disulfite, edetate disodium, anhydrous sodium sulfite).

Convex round tablets, packs of 50 and 100 pieces.

Solution for injection in ampoules, has no color, transparent or slightly yellow. Packs of 1, 2 or 10 ampoules.

Side effects

The use of the drug Etamzilat may cause the following side effects:

  • From the nervous system: dizziness, headache, hot flashes, paresthesias.
  • On the part of the immune system: fever, allergic reactions (skin rash, itching, urticaria, anaphylactic shock, angioedema).
  • On the part of the digestive system: epigastric pain, nausea, vomiting, diarrhea.
  • Since the cardiovascular system: arterial hypotension, thromboembolism.
  • Other: acute porphyria, back pain, bronchospasm.

Clinical Pharmacology

Normalizes capillary permeability in pathological processes, improves microcirculation, increases platelet adhesion, and has a hemostatic effect. With intravenous injection, the hemostatic effect develops in 5–15 minutes, the maximum effect after 1–2 hours, the action lasts 4–6 hours or more. When i / m introduction effect occurs somewhat slower.

Dosage and administration

V / V, V / m 1 h before the operation, for prophylaxis - 0.25–0.5 g (2–4 ml of a 12.5% ​​solution). With the danger of postoperative bleeding - 0.5–0.75 g (4–6 ml) per day. If necessary, during the operation, 0.25–0.5 g (2–4 ml) is injected into / into. For medicinal purposes, 0.25–0.5 g (2–4 ml) at one time, and then 0.25 g every 4–6 hours. It can be administered intravenously, added to usual infusion solutions. For metro and menorrhagia, 0.25 g every 6 hours for 5–10 days, then 0.25 g 2 times a day during hemorrhage. With hemorrhagic diathesis and diabetic microangiopathy - 0.25–0.5 g 1–2 times a day.

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The composition of the tablets etamzilat

The name of the active substance has become the name of the drug: 250 mg of etamzilat is present in each tablet. The composition of the drug is complemented by various binding components - sodium metabisulfite, starch, etc.

The medicine is put into blisters, packs with 10 or 50 tablets are offered for sale.

What is prescribed tablets etamzilat

Tablets are recommended to take when bleeding of any origin. The drug is often used by women with heavy periods to reduce the amount of blood secretion. If menstruation is different for a long time, then Etamzilat will help stop menstruation.

The drug is indicated in other cases:

  • during surgical operations performed in various medical fields - dentistry, gynecology, etc.,
  • with damage to the vascular walls, caused by diabetic angiopathy, hemorrhagic diathesis and other diseases,
  • with injuries
  • in case of emergency, for example, to stop bleeding in the organs.

How to take etamzilat tablets?

Take the tablets should be strictly prescribed by a doctor or in accordance with the instructions, which must be put in the packaging of the drug.

Most often, the doctor, prescribing treatment, selects the following dosage:

  1. With moderate menstrual bleeding, the daily dose is from 125 mg to 500 mg. The amount is divided by 3-4 times and taken at the same time interval.
  2. With heavy periods prescribed 750 mg per day. This volume is also divided by 3-4 times.
  3. With the defeat of the vascular walls, 500 mg is prescribed up to 4 times a day.
  4. In the surgical treatment and to stop bleeding in emergency cases, the doctor selects the dose individually. In such situations, not pills are most often used, but a solution for intravenous or intramuscular administration.

Take the tablets should be strictly prescribed by a doctor or in accordance with the instructions.

With the help of etamzilat you can stop the blood from an open wound. For this use a tampon, which is wetted in a solution of a drug. It is better to use the finished medicinal composition of the ampoules.

How many days?

With heavy monthly pills taken within 10 days. Begin to drink the medicine should be 5 days before the onset of menstruation. In other cases, the duration of therapy is determined by the doctor. The specialist takes into account various factors: the condition of the patient, the cause of bleeding, their abundance, etc.

From the urinary system

The manual does not contain information about side effects from the urinary system.

Skin rashes, itching and other manifestations of allergies. It is necessary to refuse Etamzilat and take antiallergic means - Loratadine, Diazolin or something else on the advice of a doctor.

During pregnancy and lactation

Etamzilat in tablet form can be prescribed to pregnant women to eliminate the risk of miscarriage. But it is not recommended to use the medicine in 1 trimester, since can harm the development of the fetus.

The active ingredient of the drug penetrates into breast milk, so it is not prescribed to women who are feeding a newborn with breast milk.

Compatibility with alcohol

The use of alcoholic beverages during therapy should be abandoned.

The only complete analogue of etamzilat is Dicynon, which is produced in the form of tablets for oral administration and solution for injection.

There are many drugs that have the same pharmacological action, for example, Vikasol, Ezelin, Aglumin. You can use herbal remedies, created on the basis of yarrow, nettle, pepper and highlander, etc. They are produced in convenient for taking dosage forms - tablets, suspension, syrup, etc.

Manufacturer

The drug is available from several manufacturers:

  • Lugansk HFZ, Ukraine,
  • GNTsLS DP Ukrmedprom, Ukraine,
  • FarmFirma SOTEKS, Russia
  • BIOCHEMIST, Russia,
  • BIOSYNTHESIS, Russia.

Igor Zubov, 44, St. Petersburg: “I work as a doctor. Etamzilat in the form of tablets is widely used as a hemostatic agent. The drug has an attractive price. There is no confidence in its effectiveness in treating all patients, but as a preventive measure it is fully justified. In surgery, it must be prescribed individually and only to stop minor bleeding. Not all colleagues agree with my opinion. ”

Irina Solovyova, 34, Norilsk: “My eldest daughter had otitis. Were treated with Zinnat as prescribed by a doctor. My daughter cried a lot, the rash began. The doctor at the clinic said it was an allergy. Antiallergic drugs did not help. We were sent for consultation to the hematology department. They were diagnosed with thrombocytopenia caused by drugs. Etamzilat was prescribed: injections were made first, and then pills were taken. Were treated for a long time, but everything went without a trace. Good medicine, but it should be taken on the recommendation of a doctor. "

Zoya Petrakova, 29, Saratov: “In the fifth month of pregnancy, there was a threat of miscarriage. The doctor prescribed etamzilat. I started to drink pills without reading the instructions. I went to a forum where this drug was discussed by pregnant women and young mothers. What they didn’t say, there’s a rickets and a lot of different diseases. The doctor reassured, saying that from the second trimester the drug is not contraindicated. Everything turned out well - my son was born healthy. ”

Composition and release form

The choice of etamzilat by most doctors is influenced by a large variety of its dosage forms. Among them etamzilat tablets and injections. In each of these preparations, the active ingredient is etamzilat. Water and special sodium salts are additionally present in the injections.

Etamzilat tablets contain 250 mg of active ingredient, an additive (sodium metabisulphite), calcium salts, starch, common binders. In a blister pack of 10 or 50 tablets. When treating children, the drug is prescribed based on the weight of the child. The use of the release form in tablets allows you to adhere to a maximum dosage of 5 mg per 1 kg of weight in a single dose.

Etamzilat injections are available in packs of 10 pcs. Ampoules of 2 ml of solution for injection, contain 125 mg of active ingredient in each milliliter of the drug.

Features of exposure to etamzilat

Due to the specific pharmacokinetics of the drug, this tool is successfully used to stop menstruation. For these purposes, etamzilat tablets are used by many women. The drug affects the permeability and strength of both capillaries and large blood vessels, strengthening them and making them more elastic. On the effects on the blood composition of the drug is neutral. But due to the activation of platelets after the use of the drug, the blood becomes more viscous.

The drug does not increase the risk of blood clots and does not increase fibrinogen in the blood. At the beginning of the process of blood clotting Etamzilat has no effect.

The effectiveness of this drug and its safety contributes to its positive effect on blood flow velocity, improvement of microcirculation in the blood when it is used. These features are the main argument because of which Etamzilat is prescribed for bleeding. Its action allows to close the bleeding place in the vessel, but not to disrupt the flow of blood and the supply of organs to it.

Use during pregnancy and lactation

As a rule, etamzilat during pregnancy is necessary to eliminate the threat of miscarriage. But in the first trimester of pregnancy, injections of the drug are prescribed only when absolutely necessary, since there is a risk of harm to the fetus.

For pregnant women in the second and more trimesters, this medicine is not dangerous. When ectopic pregnancy drug is not used. In each case, only the doctor determines how much during pregnancy, taking into account the composition of the blood and other indicators, the use of this tool is justified.

Since Etamzilat is able to penetrate into breast milk, the drug is not prescribed during lactation.

Dosing and Administration

When using Etamzilat, the instructions for use must be strictly observed. This manual is very accurate and affordable sets out all the conditions under which the use of medication is possible.

When prescribing tablets, the following dosage is observed:

  • 0.25–0.5 mg of the drug 3-4 times a day with moderate bleeding during menstruation,
  • 0.75 mg medication (3 tablets) from 3 to 4 times a day for extremely heavy periods,
  • 0.5 mg up to 4 times a day, if necessary, to cope with heavy long periods, tablets drink 10 days, starting five days before the start of menstruation.

With each ingestion, the pills begin to have an effect in about 20 minutes, the maximum effect will come in 2 or a little more than an hour.

The most effective are the injection of the drug. It is placed intravenously and intramuscularly. In the first case, the action manifests itself almost in the eyes - in less than 10 minutes.

The dosage depends on the evidence and is prescribed by a doctor. According to the instructions, when treating Etamsylate with injections, from 0.125 to 0.250 mg of the drug should be administered once, the maximum dose - 0.375 mg. The number of injections - up to 4 times per day.

In extreme cases, for example, when bleeding due to the installation of the spiral, you will need to enter up to 6 ampoules per day.

Blood can be stopped with etamzilat if there is an open wound. To do this, use a swab moistened with the preparation or a sterile bandage.

Overdose

The main treatment regimen does not imply an overdose. Therefore, no cases of exceeding the permissible doses of the drug were found.

In some cases, under the conditions when Etamzilat is used, it is necessary to take into account the possibility of its effect on the body. For example, during drug treatment, you should stop breastfeeding your baby.

Taking this medication in excessive doses does not require special measures. To eliminate the possible consequences, it is enough to cancel the drug. Almost all the injected amount is excreted by the kidneys, therefore in 3-4 days its content in the blood will cease to be a threat.

Etamzilat in ampoules

Etamzilat injections are used to prevent bleeding before and after surgery, with appropriate indications (2-4 ml intramuscularly or intravenously, one hour before surgery). If there is a risk of postoperative bleeding, 4-6 ml per day is prescribed. Possible application schemes:

  • hemorrhagic diathesis - 1.5 g, one injection per day, the duration of the course is 5-14 days,
  • in ophthalmology - 0.125 g (1 ml of solution) subconjunctivally or retrobulbar,
  • in veterinary practice - 0.1 ml per kilogram of animal weight 2 times per day.

Etamzilat during pregnancy

When pregnancy etamzilat prescribed with caution. Not recommended for use during the first trimester. In the event of bleeding or miscarriage at a later time, it is used in combination with Progesterone with constant monitoring of blood clotting. The appointment should be made by the doctor, leading the pregnancy, self-treatment can lead to negative consequences for the health of the mother or fetus.

Drug interactions

It is unacceptable to mix the etamzilat solution in the same syringe with other medications. With parallel therapy with the pharmaceutical group of dextrans, with the administration of the drug at a dosage of 10 mg / kg one hour before they are taken, the antiaggregant effect may decrease, the administration after does not have a pronounced hemostatic effect. Acceptable joint use with aminocaproic acid, menadione sodium bisulfite.

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